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Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

Cell cycle progression is one of the critical signaling mechanisms of homeostasis maintenance in healthy tissues and normal cells. Induction of cell arrest in cancer cells is a valuable strategy for anticancer drug development. Several studies support that ivermectin leads to cell cycle arrest phase in some cancer cells. In addition, ivermectin could also cause cholangiocarcinoma cell arrest at the S phase. The present study demonstrated that ivermectin induced S-phase arrest in SW480 and SW1116 cells.

In conclusion, we have demonstrated that ivermectin may regulate the expression of crucial molecules in the apoptosis pathway by increasing ROS production and inhibiting the cell cycle in the S phase to inhibit colorectal cancer cells. Therefore, current results indicate that ivermectin might be a new potential anticancer drug for treating human colorectal cancer and other cancers.

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Ivermectin Inhibiting Colorectal Cancer.pdf
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Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

Cell cycle progression is one of the critical signaling mechanisms of homeostasis maintenance in healthy tissues and normal cells. Induction of cell arrest in cancer cells is a valuable strategy for anticancer drug development. Several studies support that ivermectin leads to cell cycle arrest phase in some cancer cells. In addition, ivermectin could also cause cholangiocarcinoma cell arrest at the S phase. The present study demonstrated that ivermectin induced S-phase arrest in SW480 and SW1116 cells.

In conclusion, we have demonstrated that ivermectin may regulate the expression of crucial molecules in the apoptosis pathway by increasing ROS production and inhibiting the cell cycle in the S phase to inhibit colorectal cancer cells. Therefore, current results indicate that ivermectin might be a new potential anticancer drug for treating human colorectal cancer and other cancers.

@wokeinteldrops
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Spiking bond yields driving sharp losses in tech stocks

A spike in interest rates since the start of the year has accelerated a rotation out of high-growth technology stocks and into value stocks poised to benefit from a reopening of the economy. The Nasdaq has fallen more than 10% over the past month as the Dow has soared to record highs, with a spike in the 10-year US Treasury yield acting as the main catalyst. It recently surged to a cycle high of more than 1.60% after starting the year below 1%. But according to Jim Paulsen, the Leuthold Group's chief investment strategist, rising interest rates do not represent a long-term threat to the stock market. Paulsen expects the 10-year yield to cross 2% by the end of the year. A spike in interest rates and its impact on the stock market depends on the economic backdrop, according to Paulsen. Rising interest rates amid a strengthening economy "may prove no challenge at all for stocks," Paulsen said.

Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

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