نشریه رمزیست | United States America (US)

Create: 2022-09-15 Update: 2024-05-31 23:50:44

تأثیر منابع و ابزارهای بیوانفورماتیک ساختاری بر پژوهش‌های SARS-CoV-2

درک نقش عملکردی ساختارهای سه بعدی، برای فهم تکامل و انتقال ویروس و همچنین هدایت پژوهش‌های درمانی ضروری است. پیش از این نیز، زیست‌شناسی ساختاری در توسعۀ درمان‌های ضد ویروسی برای بیماری‌هایی چون HIV و آنفلوانزا موفقیت آمیز عمل کرده بود. در غیاب واکسن‌های قابل دسترسSARS-CoV-2، از رویکردهای بر پایۀ ساختار، جهت شناسایی آنتی‌ژن‌ها، به‌ویژه پروتئین اسپایک، عامل اصلی عفونت، جهت طراحی دارو استفاده می‌شود. اخیراً چندین مولکول دارویی بالقوه برای استفادهٔ مجدد، براساس الگوریتم‌های مبتنی بر ساختار پروتئین پیشنهاد شده‌اند.

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تأثیر منابع و ابزارهای بیوانفورماتیک ساختاری بر پژوهش‌های SARS-CoV-2

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