Core physiology volume one

Functions of HCL in stomach :
- Kills ingested bacteria
- Activates pepsinogen to pepsin & allows its action
- Maintains iron in the ferrous state to facilitate its absorption
- Facilitates absorption of calcium
- Stimulates flow of bile (by stimulating release of secretin)

‏أخشى أن تستيقظ بعد أعوام وأنت في الأربعين من عُمرك، ولا زلت ثابتًا أمام هاتفك
إقرء المزيد

الله أكبر ولله الحمد، الإعلان عن إنتهاء الحرب على غزة

الّلهم إنك عفوٌ تُحب العفو فأعف عتّا

لا مجال للصمت، لا وقت للتردد…
غزة تحت النار، وأهلها بين الحياة والموت.
اجعلوا هذا اليوم صرخة تهزّ الجمود، قوةً تُحرّك الركود، ونداءً لا يمكن تجاهله.

اجعلوها جمعةً لا تُنسى… جمعةً تهتز لها الأرض من أجل غزة!

حسبنا الله ونعم الوكيل
حسبنا الله ونعم الوكيل
حسبنا الله ونعم الوكيل

👨🏻‍⚕ : what is your name ?
💊 : my name is ceftriaxone
👨🏻‍⚕: what is your work ?
💊 : Antibiotics
👨🏻‍⚕: Tell me about yourself
💊 : I am from third Generation cephalosporin
👨🏻‍⚕ : what is your mechanism of action ?
Ceftriaxone 💊 : I'm Bacteriocidal activity results from inhibiting cell-wall synthesis , broad-spectrum against gram-negative ; has lower efficacy against gram-positive organisms
👨🏻‍⚕ : Are there's any oral compound of You ?
Ceftriaxone 💊 : No , I am only in the form of injectable solution or powder use for IV / IM
👨🏻‍⚕ : what about metabolism of you ?
Ceftriaxone 💊 : metabolized in liver
👨🏻‍⚕ What about your elimination ?
Ceftriaxone 💊 : Urine " 33% - 67% unchanged "
👨🏻‍⚕ : nurse want to ask you How ceftriaxone 💊 administration ?
Ceftriaxone 💊 : this is very important point ,
🔻You must to do Test for allergy before administration very very important heart
I am incompatible with with LR ...
👨🏻‍⚕ : so I understand some patient have hypersensitivity reaction to you and maybe fetal , also you are incompatible with LR ,
But I have Questione also there's NEWS that say Calcium is Your Enemy ?
Ceftriaxone 💊 : when I meet calcium or any calcium containing fluids , we form parecipate which maybe fetal especially in neonates
👨🏻‍⚕: what is the contraindication of you ?
Ceftriaxone 💊 : do not use me in hyperbilirubinemic neonates
Don't use me with intravenous calcium-containing .
Take care drug interactions
Intravenous administration of ceftriaxone solutions containing lidocaine
Don't use ceftriaxone in neonate
👨🏻‍⚕ What is Warning ⚠️ or percution of your uses ?
Ceftriaxone 💊 :
🔻 Elevated INR
🔻 Superinfection especially in prolonged use
🔻 Renal/hepatic impairment (concurrent): Use with caution in patients with concurrent hepatic dysfunction (impaired biliary
excretion) and severe kidney disease .
🔻 Abnormal gallbladder sonograms reported, possibly the result of ceftriaxone-calcium precipitates; discontinue if signs or symptoms of gallbladder disease occur
👨🏻‍⚕ : what is your category in pregnancy ?
Ceftriaxone💊 : pregnancy category B
👨🏻‍⚕ : what about your distribution ?
Ceftriaxone 💊 : Distributed throughout body, including gallbladder, lungs, bone, bile, and CSF (higher concentrations achieved when meninges are inflamed); crosses placenta; enters amniotic fluid and breast milk
👨🏻‍⚕ : what is your Drug Interactions ?
Ceftriaxone 💊 : it's list need tim
👨🏻‍⚕ : What is your advers effect " significant "?
Ceftriaxone 💊 : 👉Ceftriaxone-calcium precipitation
👉 Hemolytic anemia
👉 Hypersensitivity reactions (immediate and delayed)
👉 Kernicterus
👨🏻‍⚕ What is other adverse effect ?
Ceftriaxone 💊 :
>10%:
Dermatologic: Skin tightness (IM; local)
1% to 10%:

Dermatologic: Skin rash (2%)

Gastrointestinal: Diarrhea (3%)

Hematologic & oncologic: 🔻🔻Eosinophilia (6%), leukopenia (2%), thrombocytosis (5%)

🔻Hepatic: Increased serum alanine aminotransferase (3%), increased serum aspartate aminotransferase (3%)

🔻Local: Pain at injection site (≤1%), tenderness at injection site (≤1%)

Renal: Increased blood urea nitrogen (1%)

👨🏻‍⚕ : this first part of the meeting 🤝 with Mr Ceftriaxone
👨🏻‍⚕ : we will compelet Tomorrow our meeting with thank you for you
Ceftriaxone 💊 : welcome 🤗
#meeting_drug
#first_drug
#part1
@pharmacology2017