يوميات صيدلاني (Moh.Mar) 💊 | United States America (US)

Create: 2023-12-28 Update: 2024-06-03 10:00:00

ربما سمعتم عن مضاد حيوي ينتمي إلى (Cephalosporins) .. ولكنه لا يصنف ضمن أي جيل من الأجيال؟

إنه دواء "Cefiderocol" الذي اعتمدته إدارة الغذاء والدواء الأمريكية عام 2019 و اعتمده الأوروبيون عام 2020

🔸️ آلية عمله فريدة للغاية .. إذ يستغل حاجة البكتيريا لعنصر الحديد (Fe) .. فيرتبط هذا الدواء بذرات الحديد الموجودة حول الخلية البكتيرية

وعندما تفتح البكتيريا أبوابها لدخول عنصر الحديد .. يقوم الدواء بالدخول دون أن تلاحظه البكتيريا

ولذلك قامت الشركة المصنعة لل(Cefiderocol) بالتسويق له باعتباره "حصان طروادة Trojan" .. وهذا هو سر وجود شعار الحصان 🐎 على غلاف الدواء (كما في الصورة)

🔸️ يستخدم للأنواع العنيدة من التهابات المسالك البولية (UTIs) .. و التهاب الرئة المكتسب من المستشفى (HAP) .. والتهاب الرئة المكتسب من أجهزة التنفس الصناعي (VAP)

🔸️ يعطى كمغذية وريدية بطيئة جدا على مدى 3 ساعات (أبطأ من الVancomycin)

🔸️ هذا الدواء افتتح مجموعة جديدة من السيفالوسبورينات (ليست ضمن الأجيال الخمسة) تسمى:
Sidero-phore Cephalosporins

أي السيفالوسبورينات "الحاملة للحديد" .. وهو الدواء الوحيد في هذه المجموعة حتى الآن.

#منقول

يوميات صيدلاني (Moh.Mar) 💊

Forwarded from 💊❤️MMO🖤📊

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6.4K viewsالصيدلاني/محمد مروان, Dec 28, 2023 at 16:58

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يوميات صيدلاني (Moh.Mar) 💊

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ربما سمعتم عن مضاد حيوي ينتمي إلى (Cephalosporins) .. ولكنه لا يصنف ضمن أي جيل من الأجيال؟

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