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Sitting for Hours May Shrink the Brain

Prolonged sedentary behavior in adults over 50 is linked to cognitive decline and brain shrinkage in regions vulnerable to Alzheimer’s disease. Even among those who exercise regularly, spending more time sitting was associated with worse cognitive outcomes.

The effect was strongest in individuals carrying the APOE-e4 gene, a major genetic risk factor for Alzheimer’s. These findings suggest that breaking up sedentary time throughout the day may be a key strategy for protecting brain health and reducing Alzheimer’s risk, especially in genetically vulnerable individuals.

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Neuroscience & Psychology
Sitting for Hours May Shrink the Brain

Prolonged sedentary behavior in adults over 50 is linked to cognitive decline and brain shrinkage in regions vulnerable to Alzheimer’s disease. Even among those who exercise regularly, spending more time sitting was associated with worse cognitive outcomes.

The effect was strongest in individuals carrying the APOE-e4 gene, a major genetic risk factor for Alzheimer’s. These findings suggest that breaking up sedentary time throughout the day may be a key strategy for protecting brain health and reducing Alzheimer’s risk, especially in genetically vulnerable individuals.

🆔@neurocognitionandlearning
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Sitting for Hours May Shrink the Brain

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