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Correct Answer - B
Ans. is 'b' i.e., Ceftazidime

Adverse effects of cephalosporins

1.Hypersensitivity reaction - It is the most usual side effect. There is
cross allergy between penicillins and cephalosporine in 5-10% of
cases.
2.Diarrhea - due to alteration of gut flora, maximum with oral
cephradine and parentral cefperazone (cefperazone is significantly excreted in bile) → May cause pseudomembranous colitis caused by Cl. difficle.
Superinfection - Most common organisms are candida and
pseudomonas, less common are staphylococci, proteus.

Ceftriaxone achieves high concentration in bile and, as the calcium salt, may precipitate to cause symptoms resembling cholelithiasis
(Biliary pseudolithiasis).
3.Nephrotoxicity - highest with cephaloridine.
4.Bleeding - ceftriaxone, cefoperazone, moxalactam & cefamandole can cause hypoprothrmbinemia and bleeding.
Disulfiram like reaction - cefamandole, cefoperazone, moxalactam and cefotetan can cause disulfiram like reaction with alcohol.
5.Neutropenia and thrombocytopenia can be caused by ceftazidim.


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Internal Medicine Videos & books
Internal Medicine Videos & books
Cephalosporin causing
thrombocytopenia is ? #PYQ#FMGE#NEETPG#INICET
Correct Answer - B
Ans. is 'b' i.e., Ceftazidime

Adverse effects of cephalosporins

1.Hypersensitivity reaction - It is the most usual side effect. There is
cross allergy between penicillins and cephalosporine in 5-10% of
cases.
2.Diarrhea - due to alteration of gut flora, maximum with oral
cephradine and parentral cefperazone (cefperazone is significantly excreted in bile) → May cause pseudomembranous colitis caused by Cl. difficle.
Superinfection - Most common organisms are candida and
pseudomonas, less common are staphylococci, proteus.

Ceftriaxone achieves high concentration in bile and, as the calcium salt, may precipitate to cause symptoms resembling cholelithiasis
(Biliary pseudolithiasis).
3.Nephrotoxicity - highest with cephaloridine.
4.Bleeding - ceftriaxone, cefoperazone, moxalactam & cefamandole can cause hypoprothrmbinemia and bleeding.
Disulfiram like reaction - cefamandole, cefoperazone, moxalactam and cefotetan can cause disulfiram like reaction with alcohol.
5.Neutropenia and thrombocytopenia can be caused by ceftazidim.


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Correct Answer - B

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