🛑 Morphological Abnormalaties Of Neutrophil ⁉
These conditions include the more ‼frequently observed disorders of:?
♦ toxic granulation
♦ Döhle bodies
♦ hypersegmentation
⭕⭕ as well as rarely observed disorders such
♦Pelger-Huët
anomaly
♦May-Hegglin anomaly
♦ Chédiak-Higashi syndrome
♦ Alder-Reilly inclusions.
🛑Hypersegmentation
⭕Hypersegmentation is most frequently seen in
neutrophils with more than five lobes or nuclear segments ..
⭕This condition is frequently associated with defiecencies of
vitamin B12 or folic acid .
⭕Pseudohyprer segmentation may be seen in old segmented neutrophils.
🛑Toxic Granulation
This is a condition in which prominent dark granulation‼
either fine or heavy ..
♦can be observed in band and segmented
neutrophils or monocytes ‼⁉Toxic granules are
azurophilic (primary) granules that are peroxidase-positive.
♦The granulation may represent the precipitation of ribosomalprotein (RNA) caused by metabolic toxicity within the cells.
♦. This condition
seen in many conditions such as ‼burns ..and non malignant disorders ..or
as the result of drug therapy.
🛑Döhle Bodies
These inclusion bodies are seen as single or multiple, light-
blue–staining inclusions on Wright-stained blood smears
.
⭕They are usually seen near the periphery of the
cytoplasm.
⭕These inclusions are predominantly seen in
neutrophils although they may be seen in monocytes.
⭕Döhle bodies represent aggregates of roughendoplasmic reticulum (RNA).
⭕may be associated with ❓
viral infections...burns...
certain drugs.
🛑Pelger-Huët Anomaly
♦This is genetically acquired autosomal dominant disorder pro-
duces‼ hyposegmentation of many of the mature neutrophils ..
♦ The nuclear shape may resemble dumbbell ‼or pair of eyeglasses. Although the segments fail to lobulate normally .
♦.pseudoanomaly may be ‼drug induced or may occur in acute infections. .The function
of the cell is considered to be normal despite the morphological abnormal.
@labinformation7
🛑May-Hegglin Anomaly
♦This genetic condition is characterized by the presence of Döhle body–like inclusions in neutrophils eosinophil and monocytes ..
♦Abnormally large and poorly granulated platelets ‼‼and thrombocytopenia frequently coexist in this condition. .
♦ approximately 50% of patients do not ‼have
symptoms others have manifested ‼abnormal bleeding tendencies..
♦The cause of the hemostatic defect is unclear, but it proportionate to the degree of thrombocytopenia.
🛑Chédiak-Higashi Syndrome
♦♦ rare disorder is a hereditary disease‼ autosomal recessive trait
♦It is primarily seen in children and young adults ..
♦is characterized by very large granules These peroxidase positive ‼deposits represent abnormal
lysosomal development in neutrophils and other leukocytes..
♦Neutrophils display
impaired chemotaxis and delayed killing of‼‼ ingested bacteria..
♦Patients with this disorder suffer from frequent infections which suggest that neutrophils with this defect are not efficient bacteriocidal cell..
🛑Chédiak-Higashi Syndrome
⭕⭕rare disorder is a hereditary disease‼ autosomal recessive trait
⭕It is primarily seen in children and young adults ..
⭕is characterized by very large granules These peroxidase positive ‼deposits represent abnormal
lysosomal development in neutrophils and other leukocytes..
⭕Neutrophils display
impaired chemotaxis and delayed killing of‼‼ ingested bacteria..
⭕Patients with this disorder suffer from frequent infections which suggest that neutrophils with this defect are not efficient bacteriocidal cell ..
🛑Alder-Reilly Inclusions
♦purple-red particles are precipitated ‼‼ mucopolysaccharide seen primarily in?? neutrophil
@labinformation7
>>Click here to continue<<