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Generally, about 50% of pediatric brain tumors are gliomas, with an equal distribution of low -grade gliomas (LGG) and high-grade gliomas. The high grade brainstem glioma and high grade supratentorial glioma account for 20% of childhood gliomas respectively, with the remaining 5% happening in the cerebellum. High-grade gliomas are categorized as anaplastic astrocytomas (AA) and glioblastoma (GBM). Gliomas are among the most diverse group of brain tumors affecting children, and these tumors in children span a wider range of pathologic subtypes and prognosis than any other neoplasm as a whole. This clinical diversity is matched by the wide array of genetic alterations and how mutations may affect tumorigenesis. However, response to therapy is yet to be discovered.

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Generally, about 50% of pediatric brain tumors are gliomas, with an equal distribution of low -grade gliomas (LGG) and high-grade gliomas. The high grade brainstem glioma and high grade supratentorial glioma account for 20% of childhood gliomas respectively, with the remaining 5% happening in the cerebellum. High-grade gliomas are categorized as anaplastic astrocytomas (AA) and glioblastoma (GBM). Gliomas are among the most diverse group of brain tumors affecting children, and these tumors in children span a wider range of pathologic subtypes and prognosis than any other neoplasm as a whole. This clinical diversity is matched by the wide array of genetic alterations and how mutations may affect tumorigenesis. However, response to therapy is yet to be discovered.
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