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Create: 2025-05-11 Update: 2025-07-10 17:46:42

🗞تومور مغزی زیر ذره‌بین خون: روشی نوین برای ردیابی پیشرفت گلیوما

👩‍🔬پژوهشگران کلینیک مایو (Mayo Clinic) در مطالعه‌ای نوآورانه، روش جدیدی برای پایش پیشرفت گلیومای درجه بالا (high-grade glioma) معرفی کردند. آن‌ها با استفاده از آزمایش خون شخصی‌سازی‌شده بر اساس DNA تومور هر بیمار، توانستند پیشرفت سرطان را سریع‌تر و کم‌تهاجمی‌تر نسبت به روش‌های سنتی مانند تصویربرداری یا بیوپسی تشخیص دهند.

🩸این پژوهشگران از خون بیماران مبتلا به گلیوما نمونه‌گیری کردند و با تحلیل DNA آزاد شده از سلول‌های تومور (ctDNA)، تغییرات ژنتیکی خاص هر بیمار را شناسایی نمودند. سپس با استفاده از این اطلاعات، یک تست "شخصی‌سازی‌شده" برای پایش بیماری طراحی شد.

❗تست‌های خون سنتی نمی‌توانند به‌خوبی گلیوما را پایش کنند چون این تومورها کمتر DNA به جریان خون نشت می‌دهند.
این گروه با طراحی آزمون دقیق و اختصاصی برای هر بیمار بر اساس جهش‌های تومور خودش توانستند حساسیت روش را به‌طرز چشمگیری بالا ببرند.

✅ مزایای کلینیکی این روش عبارت است از:

۱-کاهش نیاز به MRI مکرر یا جراحی برای بیوپسی.
۲-پایش سریع‌تر پاسخ به درمان یا بازگشت بیماری (recurrent glioma).
۳-امکان تشخیص میکرومتاستاز یا رشد اولیه مجدد تومور حتی قبل از قابل مشاهده شدن در تصویربرداری.

✒نویسنده: فائزه رضایی
ویراستار : رضا منصوری مهر

🗂منبع

#NeuroUpdates
#نوروساینس_روز

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Neuroscience News

Blood Test Tracks Brain Tumor Growth with Patient-Specific DNA Markers

Researchers have developed a personalized blood test that may offer a faster, less invasive way to track high-grade glioma progression.

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1.04K viewsGhazal Hafez, edited May 11 at 09:49

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🗞تومور مغزی زیر ذره‌بین خون: روشی نوین برای ردیابی پیشرفت گلیوما

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