آکادمی میکروب‌شناسی ایران | United States America (US)

Create: 2025-05-30 Update: 2025-07-08 23:59:42

💢 راز مقاومت باکتری‌ها در برابر یک آنتی‌بیوتیک قوی!

🧫 مقاومت به آنتی‌بیوتیک‌ها یکی از جدی‌ترین چالش‌های حوزه پزشکی است. پژوهش‌های مولکولی اخیر نیز نشان می‌دهند، باکتری‌هایی مانند استافیلکوکوس اورئوس توانسته‌اند در برابر اسید فوزیدیک "دارویی که با مهار سنتز پروتئین، رشد باکتری را متوقف می‌کند" مقاومت نشان دهند.

🔬 این مقاومت به‌واسطه‌ی پروتئین "FusB" رخ می‌دهد که با مکانیسمی منحصربه‌فرد، عامل ترجمه‌ی مسدودشده "EF-G" را از ریبوزوم آزاد می‌سازد و بدین‌ترتیب اثر مهاری دارو را خنثی می‌کند. این سازوکار ضمن توضیح چگونگی مقاومت در برابر دارو، درک عمیقی از استراتژی های پیشرفته باکتری ها برای فرار از تاثیر آنتی بیوتیک ها را ارائه می دهد.

🔻 اما مکانیسم آن چگونه است ؟

1. اتصال FusB به EF-G

2. آزادسازی EF-G از ریبوزوم

3. اتصال FusB به ریبوزوم در غیاب EF-G

نویسنده : ملیکا ضابطیان‌ حسینی

📌 لینک خبر

📚 برای دریافت رفرنس کلمه "مقاله" را ریپلای کنید.
𓂃◌𓈒𓐍𓂃◌𓈒𓐍𓂃◌𓈒𓐍𓂃◌𓈒𓐍𓂃◌𓈒𓐍

💠 Community/ Instagram/ Zilink

╭─────•⊰𓐍⊱•──────╮
🦠@ir_micro_academy🧪
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Pinterest (PINS) closed at $71.75 in the latest trading session, marking a -0.18% move from the prior day. This change lagged the S&P 500's daily gain of 0.1%. Meanwhile, the Dow gained 0.9%, and the Nasdaq, a tech-heavy index, lost 0.59%. Heading into today, shares of the digital pinboard and shopping tool company had lost 17.41% over the past month, lagging the Computer and Technology sector's loss of 5.38% and the S&P 500's gain of 0.71% in that time. Investors will be hoping for strength from PINS as it approaches its next earnings release. The company is expected to report EPS of $0.07, up 170% from the prior-year quarter. Our most recent consensus estimate is calling for quarterly revenue of $467.87 million, up 72.05% from the year-ago period.

💢 راز مقاومت باکتری‌ها در برابر یک آنتی‌بیوتیک قوی!

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