health professions🧠 | United States America (US)

Create: 2024-05-09 Update: 2024-06-05 18:35:07

لا يفضل إعطاء Ceftriaxone للأطفال حديثي الولادة الي تكون أعمارهم أقل من شهر بس ليش⁉️

بسهولة لان الceftriaxone قابليته على الارتباط ب albumin تكون عالية وبدليل ان Half life مالته يوم كامل‼️

زين واذا ارتبط ceftriaxone ب albumin شنو المشكلة⁉️
مو اذا ارتبط ceftriaxone ويه albumin راح يسوي ازاحة او displacement لل Bilirubin من موقع ارتباطة ب albumin ويرتبط بمكانه‼️
وشنو المشكلة خل يرتبط⁉️
مو لازم تعرف احنه اصلا عدنه مستوى Bilirubin بالاطفال حديثي الولادة راح يكون عالي لان نسبة تكسر الكريات الحمر ب neonate تكون اعلى من الاطفال البقية لان life span مالت RBC عدهم قصيرة اقل من ١٢٠ يوم⁉️
زين هسة وبعدين شنو راح يصير اذا صارلها ازحة من نستخدم ceftriaxone!!
راح تزيد عن الحد الطبيعي بالدم وبما انو اني عندي نسبة unconjucated bilirubin عالية راح تصعد للدماغ وتسوي شي نسمي kernicterus jaundice وهالشي يعتبر permanent neurological damage لذلك ميصير نستخدم ceftriaxone للاطفال حديثي الولادة واذا جانت اكو حاجة لاستخدم cephalosporin ممكن نستخدم cefotaxime وصحة والف سلامة♥️🙏

health professions🧠

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health professions🧠

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لا يفضل إعطاء Ceftriaxone للأطفال حديثي الولادة الي تكون أعمارهم أقل من شهر بس ليش⁉️

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