元朗疾病管制與預防中心 YLCDC | United States America (US)

Create: 2022-03-03 Update: 2025-07-09 22:18:44

#武肺疫苗 #後續副作用

復必泰的逆轉錄
近日網上流傳一篇研究，表明了武肺mRNA疫苗復必泰，也就是文中的BNT162b2，會在肝臟細胞中逆轉錄成DNA。小編也詳細閱讀了這一研究。

先說結論，這個研究的確證明了復必泰在肝臟細胞中會被轉錄成DNA，但目前也僅此而已，將來更多影響需要進一步研究。

在這個研究中，證實了兩個事實。

一個是注射復必泰後，人類逆轉錄酶和轉座子LINE-1的表達量提升了。LINE-1可將RNA逆轉錄成DNA，並且將非內源性DNA整合進人類基因組。

另一個是復必泰的確在肝臟細胞中會被逆轉碌成DNA。

但以上兩個就是文章的結論，文章並未證明復必泰的DNA會被整合進人類基因組，因此仍需後續觀察。而如果真的被整合進人類基因組，可能影響基因組完整性，後果之一最易理解的就是致癌。

武肺核酸可被整合到人類基因組
另外也有一篇文章也證明了武肺病毒感染者體內基因組的確被整合進了一些武肺病毒片段。文章中證明了LINE-1會將病毒基因組片段整合進人類基因組，並可能會令病人的武肺核酸檢測呈陽性。

但該文章中所述的武肺病毒片段，主要是武肺病毒接近尾端的次基因組片段，而非復必泰的武肺S蛋白mRNA，因此LINE-1和復必泰的互動會否因此而有所影響呢？復必泰DNA會否被整合入人類基因組呢？尚須更多研究。

相關管理標準
在現行的歐洲和英國在對BNT162b2的風險管理中，由於其主要成份是RNA和脂質，不被視為能夠影響基因組完整性和遺傳細胞基因，而且未有研究指出其成份會致癌，因此未將致癌性和遺傳毒性行納入風險管理的考慮範圍內。

一切都要等更新研究發掘了。========================

我們是自發建立的民間智庫組織，致力普及與健康相關的資訊、情報及提供相關分析。

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#武肺疫苗 #後續副作用

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