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Create: 2024-02-28 Update: 2024-05-29 07:36:53

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عند استخدام دواء Methotrexate (بجرعات عالية) يمنع إعطاء المريض أحد أدوية ال NSAIDs ؟

لأن جميع أدوية ال NSAIDs بتمنع خروج ال Methotrexate من الجسم مما يسبب :

Increased risk of methotrexate toxicity, Reduced active metabolite formation and Possibly reduced methotrexate efficacy.

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