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Create: 2024-01-11 Update: 2024-06-09 11:51:11

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💢 Celiac disease

هو أعتلال معوي ناتج عن إستجابه مناعية خاطئه لبروتين الغلوتين ( gluten) و الجليادين (gliadin ) (الموجودين في الاطعمه المعموله من القمح او الشعير او الشوفان... وغيرها)

🔸آلية هضم الغلوتين

يتم تكسير بروتين الغلوتين gluten في الامعاء الى الغليادين gliadin والذي يتفكك الى جزئيات أصغر تدعى deamidated gliadin peptide وذلك بمساعدة انزيم Transglutaminase

🔸 آلية حدوث المرض

عند مرضى السيلياك يستجيب الجهاز المناعي ضد نواتج هدم الغلوتين بسبب خلل في جينات
HLA (human Leukocyte antigen)
وهذه الجينات هي المسؤولة عن التفريق بين الراسمات السطحية (antigens) الغريبه والمعروفه

ونتيجه لهذا الخلل يظهر في سطح الخلايا اللمفاويه والماكروفاج راسمات سطحية تدعى HLA-DQ2 /HLA-DQ8 وعند ارتباط بقايا الغلوتين بهذه المستقبلات تتعرف تلك الخلايا على هذه المركبات انها غريبه وتبدا بتحفيز المناعة فيتم إطلاق السيتوكينات (المسببه لالتهاب وتنخر الامعاء ) و أجسام مضاده ضد تلك المركبات وضد الامعاء و الإنزيمات المرتبطة بعملية هضم وامتصاص الغلوتين مثل إنزيم transglutaminase

👈 مما يسبب تلف و إعاقة لوظيفة الامعاء الدقيقه في إمتصاص الطعام ليظهر عند المريض أهم أعراض هذا المرض وهو 👈 #سؤ_الإمتصاص
#يتبع..

#عبدالرحمن_شراق
@A_sheraq
@LabMed2016

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4.7K viewsعبدالرحمن شراق, edited Jan 11 at 16:21

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Telegram Be The Next Best SPAC

I have no inside knowledge of a potential stock listing of the popular anti-Whatsapp messaging app, Telegram. But I know this much, judging by most people I talk to, especially crypto investors, if Telegram ever went public, people would gobble it up. I know I would. I’m waiting for it. So is Sergei Sergienko, who claims he owns $800,000 of Telegram’s pre-initial coin offering (ICO) tokens. “If Telegram does a SPAC IPO, there would be demand for this issue. It would probably outstrip the interest we saw during the ICO. Why? Because as of right now Telegram looks like a liberal application that can accept anyone - right after WhatsApp and others have turn on the censorship,” he says.

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