مبارزه قارچ‌ها با ویروس‌ها از طریق ویرایش RNA @آکادمی ژنتیک ایران

آکادمی ژنتیک ایران | United States America (US)

Create: 2025-06-11 Update: 2025-07-10 03:17:57

مبارزه قارچ‌ها با ویروس‌ها از طریق ویرایش RNA

🍄‍🟫محققان ژاپنی در مطالعه‌ای، مکانیسمی را در قارچ‌ها علیه ویروس‌ها کشف کرده‌اند که پاسخ ژنتیکی قارچ را در سطح ژنوم تغییر می‌دهد و انتقال ویروس‌ها را محدود می‌کند.

🪄مکانیسم ویرایش RNA در قارچ Neurospora crassa، آنزیم‌هایی تولید می‌کند که بر روی mRNA تأثیر می‌گذارد و با تغییر کدون‌های توقف، باعث ادامه‌ی ترجمه پروتئین‌های کلیدی می‌شود. این پروتئین‌ها، رونویسی را برنامه‌ریزی می‌کنند و پاسخ‌های ضدویروسی شکل می‌گیرد.

🪧همچنین یافته‌ها نشان دادند که اگر سیستم تداخل RNA (RNAi) در قارچ غیرفعال شود، این مسیر ویرایش RNA به‌عنوان یک خط دفاعی جایگزین، فعال می‌شود.
حذف RNAi باعث می‌شود آنزیم‌های ویرایش بیش از حد بیان شوند و به طور مؤثرتری کدون‌های توقف را ویرایش کنند؛ در نتیجه پاسخ‌های ضد ویروسی شدیدتر و علائم ویروسی جدی‌تری ظاهر می‌شود.

💯این مطالعه نقطه عطف مهمی در توسعه کاربردهای منحصربه‌فردی در مهندسی ژنتیک و سویه‌های قارچی با پتانسیل ضد ویروسی قوی است.

✍🏻مترجم: ساغر صنعتی
📥منبع: Phys

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